疣皮
1.a uniformly warty stocky toad of washes and streams of semiarid southwestern United States.
2.Among high risk type in over 100 HPV genotypes, HPV16 plays a major role in the pathogenesis of condyloma acumilatum(CA), cervical cancer and cervical intraepithelial neoplasia.
3.A thorny evergreen shrub or small tree(Citrus medica) native to India and widely cultivated for its large, lemonlike fruits that have a thick, warty rind.
4.Elephantiasis nostras verrucosa describes the cutaneous changes including dermal fibrosis, hyperkeratotic, verrucous, and papillomatous lesions that occur after chronic secondary, nonfilarial lymphedema.
5.Method: Detected the HSV- Ⅱ, CMV, HPV6/11, Rb, E2F1, HPV16E7 of 10 nomal cervix. 10 chronic cervicitis ,10 cervical condyloma ,45 CINs and 20 cervical carcinoma by Immunohistochemistry, detected HPV16CDNA by in situ hybridization. Result: Cervical condyloma has a great higher HPV6/11 infection rate.
6.Methods:Detected the Rb,E2F1,HPV16E7 of 10 nomal cervix. Ten chronic cervicitis,10 cervical condyloma,45 CINs and 20 cervical carcinoma by Immunohistochemistry.
7.Method In immunohistochemistry detection P16INK4A , CyclinE,CDK2 of expression(Detection P16INK4A ,CyclinE using SP method;Detection CDK2 using SABC method)and in situ hybridization detectionHPV16 in 15 nomal cervix,10 cervical condyloma ,45 CINs and 20 cervicalcarcinoma Using Tissue Microarra.
8.Methods HPV6/11,HSV-Ⅱ and CMV of 10 cases of nomal cervix,10 chronic cervicitis,10 cervical condyloma,45 CINs and 20 cervical carcinoma were detected by the immunohistochemistry,and HPV16 cDNA by in situ hybridization.
10.Verrucous carcinoma is composed of lobules of mature squamous epithelium with minimal atypia, but they are ulcerating or fungating.

