罗培南
1.We have synthesized faropenem by fouteen steps from the material of 6-APA.
2.Methods The minimum inhibitory concentrations (MICs) of meropenem agai nst 110 clinical isolates producing a-lactamases were determined by agar dil ution method,in comparison to 10 other antimicrobial agents.
3.The three agents were highly active against Enterobacteriaceae, and they also possessed good antimicrobial activity against P.aeruginosa, Acinetobacter spp and E.faecalis.
4.After a single i.v. administration of 75 mg/kg of meropenem in each rabbit, drug concentrations reached (38.36±14.17) μg/ml immediately in bile, which significantly exceeded the minimum inhibitory concentrations (MIC_ 90 ) for most gram negatives, which range from 0.031 to 2 μg/ml.
5.The susceptibility test in vitro showed that ESBLs-producing strains h ave high resistance rate to amikicin,gentamicin,ciprofloxacin, while the resista nce rate to these three agents was 37.0% ,68.5% , and 64.8% separately. Carbe npenems such as impenem and meropemam are stable against ESBLs,the sensitive rat e was 100% .
6.There was no change in the resistant rate to levofloxacin cefoperazone/sulbactam and ampicillin/clavulanic, resistant rate to fosfomycin and aztreomam declined; resistance to levofloxacin, meropenem, cefoperazone/sulbactam and ampicillin/sulbactam were low and preferred for antimicrobial treatment.
