Philadelphia chromosome(Ph chromosome)
1.Objective To study the bcr/abl fusion gene in chronic myeloid leukemia (CML) cases with Philadelphia chromosome(Ph)negative,and variant Ph translocations and other chromosome anomalies.
3.Results: Before blastic crisis, Philadelphia chromosome (ph) were positive in 18 cases, and negative in 2 patients.
4.CML is caused by a reciprocal chromosome translocation between chromosome 9 and 22, resulting in the short Philadelphia (Ph) chromosome carrying the BCR-ABL (Breakpoint Cluster Region-Abelson Leukaemia) oncogene.
5.Objective To observe the effect of autologous dendritic cells (DC) on positive Philadelphia(Ph +) chromosome cells of Chronic Myeloid Leukemia (CML) in vitro.
6.It is generally believed that the Philadelphia (Ph) chromosome plays a key role in the origination of CML, which confers on its progeny a proliferative advantage over normal hematopoietic elements and thus allows the Ph+positive clone gradually to displace residual normal hematopoiesis.
7.Objective: Chronic myeloid leukemia (CML) is a common malignant hematopoietic disease. More than 90% of patients with CML have the Philadelphia (Ph) chromosome which produces a specific oncoprotein known as BCR/ABL (P210) protein.
