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1.ICAM-1 is an accessory molecule stabilizing the T-cell receptor-mediated binding between antigen-presentingcells and T lymphocytes, and serves as a cofactor in the activation of the cellular immune response.
ICAM-1能辅助稳定T细胞受体介导的抗原呈递细胞(Antigen-presenting cells,APC)和淋巴细胞的结合,是细胞免疫协同激活因子。收藏指正
2.An optimal T cell response is achieved by a combination of signals delivered through the antigen-specific T cell receptor (TCR) engagement of the peptide-major histocompatibility complex (MHC) on antigen presenting cells(APCs) and accessory signals provided by the interaction of receptors on T cells with their ligands on APCs and is referred to as costimulation.
研究表明,诱导T淋巴细胞活化、增殖及分化为效应细胞需要双信号刺激:第一信号来自抗原由TCR转导并由粘附分子增强; 第二信号即协同刺激信号由APCs表面的协同刺激分子和T细胞的相应受体相互作用后产生。收藏指正
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