allosteric
1.allosteric effect
3.Allosteric enzymes may have more than one modulator.
4.Allosteric enzyme An enzyme whose catalytic activity can be modified by the noncovalent binding of a particular metabolite (a modulator)at a site(the ALLOSTERIC SITE)other than the active site.
5.CLINICAL OBSERVATION OF THERAPEUTIC EFFECTS OF ALLOSTERIC SNAKE NEUROTOXIN SN 114 CASES OF MOTOR NEURON DISEASE
6.Allosteric site A part of an enzyme to which a specific effector or modulator can be attached.
7.A small molecule that when bound to the allosteric site of an enzyme causes either a decrease or an increase in the activity of the enzyme.
8.But APV and MK-801 were toxic inthemselves, Kyn as an endogenous allosteric antago-nist of the N-methyl-D-asl)artate receptor is low intoxicity.
9.Only when theenzyme was saturated by dCMP or allosteric activator dCTP, dAMPbehaved as a net isosteric competitive inhibitor. The inhibitory constantwas 4×10~(-5)M, which was much smaller than the Kms for dCMP for thetwo conformations of the enzyme.
