2.RESULTS The hepatoma cells transfected with IGF-Ⅱ R antisense gene exhibited significant reduction in endogenous IGF-Ⅱ R messenger RNA (mRNA) levels.
3.It has been shown that this occurs in bacteria in that antisense RNA sets up base pairs with a certain messenger RNA (m-RNA) precisely where the ribosomes would start their reading.
5.Objective: To explore the effect of liposome transfection antisense phosphorothioate oligodeoxynucleotide directed against the coding region of the bcl-2 messenger RNA and the translation site, and G3139 on apoptosis in Raji cells.
6.Uppsala University scientists have discovered an entirely new process in which short, tiny "antisense RNA" competes with the protein-producing ribosomes for starting sites for reading messenger RNA.
7.Results Antisense peptide nucleic acid (PNA) targeting the coding region of the bcl 2 messenger RNA can effectively inhibit HL 60,K562 cells viability ,down regulate the synthesis of bcl 2 protein and increase cell apoptosis.
8.Antisense nucleic acid technique is a method using single-stranded complementary sequences with specificity assigned by Watson-Crick base-pairing targeted specific messenger RNA or DNA to block expression of target gene.
9.Objective:To explore the effect of antisense phosphorothioate oligodeoxynucleotide (ASODN) directed against the 5` untranslated region, the translation site and the coding region of the bcl 2 messenger RNA on apoptosis in K562 cells.
