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2.The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic ariant of prostatic adenocarcinoma (no basal cell layer).
3."Although the simplest model for a CN affecting gene actiity is where the ariant is a deletion of a gene or part of a gene, we found examples where actiity is affected from a distance," commented Barbara Stranger, first author and post-doctoral fellow at the Wellcome Trust Sanger Institute. "This may occur when the CN reduces the effectieness of a region that works to switch the genes on or off.
