arterial oxygenation
1.Section 1: Effects of carbon monoxide inhaled on arterial oxygenation of rats with acute lung injury induced by lipopolysaccharideObjective: To observe the effects of carbon monoxide (CO) inhaled on arterial oxygenation and carboxyhemoglobin (COHb) level of rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS).
2.Results①PaO_2 increased significantly since 1 hour after inhalation injury,and rabbits had better arterial oxygenation within 4 hours. PaO_2 and PO_2 a/A in HFOV group were better than those in CMV group since 2 hours after inhalation injury,and there existed significant difference.
3.Results Pressure of artrial oxygen partial(PaO 2)and oxygenation index(PaO 2/FiO 2)were greatly improved, mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance(PVR) were greatly decreased during therapy.
4.The arterial blood samples were collected for blood gases analysis immediately 20 minutes after two-lung ventilation (TLV) in the supine position after anesthesia (T1) and the end of operation (T2). The values of PaO2, PaCO2, pH and the inspired oxygen fraction (FiO2) were recorded and the values of oxygenation index (OI) were calculated respectively.
5.Methods:Ten patients of EHF with acute respiratory failure were treated with continuous hemodiafiltration for 12 hours each time,changes in blood urea nitrogen and creatinine,oxygen saturation,oxygenation index(PaO-2/FiO-2),respiratory rate,central venous pressure,mean arterial blood pressure and heart rate were measured before and after hemodiafiltration.
