cell lineage
8.Immunophenotyping, cytogenetics and T cell receptor (TCR) gene and immunoglobulin heavy chain gene(IgH) rearrangements of the HTL 90 cell line were further analyzed. On immunophenotyping, HTL 90 cells expressed an antigenic profile (CD 7+/CD 34 +/HLA-DR+/CD 4-/CD 8-) indicated that they were multipotent lymphoid precursor cells with a tendency of differentiation toward T cell lineage.
9.Commitment of hematopoietic stem cells into early B-cell lineage depends on several transcription factors, including E2A, EBA and Pax-5. In Bcl-6-/- mouse, germinal center formation was impared.

