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1.1 500 000IU/m2; 2 000 000IU/m2Each group included 3 patientsThe patients received the drug in 250ml ivin 2 hours,once a day,for 7 consecutive daysOf 20 patients, 2 discontinued the trial because of patients? refusing and 18 finished the trialThe main side effect were chilly,shiver,fever,abnormal blood pressure,leukopenia,and aching pain in muscles,etcThe most side effects were grade Ⅰ.
[方法]设计6个剂量组 ,每组3例 ,以30万IU/m2 为初始剂量 ,按60、90、120、150和200万IU/m2 剂量渐次递增 ,受试病人在2小时内静脉滴注250ml药液 ,每日1次 ,连续7天。 [结果]20例肿瘤病人入组 ,除2例因故出组外 ,其余18例均按计划完成试验。收藏指正
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