cleavage form
1.The results demonstrated C—N bond cleavage and N—N bond cleavage of HMX occur in heating temperature, and C—N bond cleavage is dominant rupture form. Gas products such as CO_2,N_2O,CO,NO,HCHO,HONO,NO_2 and HCN were investigated. The decomposition kinetic equation of HMX is k_(C-N)=e~(34.6)exp(-152/RT).
2.The interaction of the complex with pBR322 DNA has been investigated by agarose gel electrophoresis. The complex has been found to promote cleavage of pBR322 DNA from supercoiled form Ⅰ to the open circular form Ⅱ and to linearized form Ⅲ, showing that the complex has high cleaving efficiency to DNA.
3.The key intermediate,1 [8 methylamino 1 oxaspiro[4.5]dec 7 yl]pyrrolidine(16) was prepared from 1, 4 cyclohexadione via condensation, spirocyclization, reduction, epoxidation, the epoxy ring was opened with methylamine to give a mixture of aminoethanols followed by ring closure and then cleavage. 16 was acylated with 4 benzofuranacetic acid in the presence of the coupling agent CDI to form enadoline.
4.The porcine brain natriuretic peptide(BNP-26) and its analog, (Mpr~4 ,D-AIa~(6,13)) BNP(4-24)-NH_2, were synthesized by solid phase method employing the Boc strategy. After HF cleavage to remove the protected groups, the crude linear peptide was air-oxidized under alkaline conditions to form the disulfide bridge.
