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1.Half of every group rabbits were killed respectively at the end of 8,12 weeks to detect blood glucose value(BG),kidney weight/body weight ratio(KW/BW),urine retinol-binding protein(RBP),N-Acetyl-β-D-Glucosaminidase(NAG) concentration.
第8周、第12周时分别测各组半数兔血糖、肾重、体重、尿视黄醇结合蛋白(RBP)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)。收藏指正
2.AIM: To study whether there is a high affinity receptor for advanced glycosylation end product (AGEP) on thoracic aorta smooth muscle cells (ASMC) and to test effect of diltiazem on elevation of cytosolic free calcium induced by AGEP. METHODS: Interactions of AGEP bovine serum albumin (BSA) with ASMC were studied with radioligand binding assay and cytosolic free calcium ([Ca 2+ ] i) was examined in cultured ASMC with Fura 2 AM.
目的:探讨培养的主动脉平滑肌细胞(ASMC)上是否表达糖基化产物(AGEP)高亲性受体和地尔硫?对AGEP升高胞浆游离钙的抑制.方法:用放射配基结合方法研究ASMC与AGEP的相互作用;收藏指正
3.2. Losartan can protect the kidney from diabetic injury and its mechanism probably is that losartan inhibit the progress of angiotensin-Ⅱ binding to its recepter and affect DAG-PKC’S activation. In the end, the expression of PKC-β decreased, which reduced the expression of TGF-β, TIMP-1.
2.氯沙坦对糖尿病大鼠肾脏有保护作用,其机制可能是通过抑制血管紧张素Ⅱ(AgⅡ)与其受体AT1结合,进而影响二酰甘油(DAG)-PKC活化途径,使PKCβ表达减少,达下调TGF-β1和TIMP-1的效果。收藏指正
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