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1.Objective: To study folate-conjugated albumin nanoparticles targeting to tumor cells via folate receptor-mediated endocytosis.
摘要目的研究能通过叶酸受体介导靶向肿瘤细胞的叶酸偶联白蛋白纳米粒。收藏指正
2.Conclusion: Folate-BSANP could be delivered into tumor cells via folate receptor-mediated endocytosis and significantly targeted to tumor cells with rich folate receptors.
结论叶酸偶联白蛋白纳米粒能通过细胞膜上的叶酸受体介导内吞入胞，可显著靶向于叶酸受体丰富的肿瘤细胞。收藏指正
3.The soluble FBP are found in serum, cerebrospid fluid and cytoplasma, called as sFR, but membrane-associated FBP, which are found in various types of cells, are divited into two kinds , folate receptor(FR) and reduced folate carrier(RFC) in recently. FR have a high-affinity to folic acid and RFC have a more-affinity to reduced folate compounds, such as 5-formyltetrahydrofolate and MTX.
另一类是存在于多种细胞膜表面的FBP。 最近发现这些FBP实际分为两种，一种为与叶酸有较高结合力的叶酸受体(FR)，第二种与还原叶酸如5-甲酰基四氢叶酸、MTX有较高结合力，称为还原叶酸载体(RFC)。收藏指正
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