immortalization
1.Chromosomal Aberration and HPV18 E6,EPV18 E7 Expression in Esophageal Epithelial Cells during Immortalization and Malignant Transformation
2.Reversible Immortalization of Human Melanocytes Mediated by SV40 Large T Antigen and Cre/loxP Site-Specific Recombinase System
3.Telmerase, a kind of reverse transcriptase, can use its own RNA template to synthesize the repeated sequences (5-TTAGGG-3)n of telomere DNA, and adds them to the chromosomes ends, maintains telomere length, results in cellular immortalization or oncogenesis. Telomerase was composed of six subunits: human telomerase RNA (hTR), telomerase associated protein (TP-1), human telomerase-reverse transcriptase (hTERT), heat shock protein (hsp90), molecular companion (p23) and dyskerin.
