leading sequence
1.Results NF κB decoy could be successfully transfected into HUVEC. It could compete with the endogenous κB cis sequence element in the regulatory regions of TF promoter to bind transcriptional factor NF κB. It could also significantly inhibit the TF mRNA ,TF antigen expression on the cell surface and TF function leading to activation of FⅦ.
2.In this study the quinolone-sensitive strain and standard sensitive strain-ATCC27853 had the same sequence as reported. By DNA-sequencing R25,R42,R43 and R44 resistant strains were found having an TCG-to-TTG mutation in codon 87,leading to the amino acid substitution of a Serine for a Leucine. In addition,a new silent mutation(GCT-to-GCG) were found in codon 115,which did not lead to amino acid change.
