lithogenic
1.Conclusions Piperine may prevent the formation of cholesterol gallstone through inhibiting the lithogenic role of APN.
2.Compared with the control group, bile surrounding cholesterol store had high lithogenic index (LI=1.50) and high CA/CDCA ratio.
3.Four index of lithogenic tendency of bile: LI,UCB%,BSI and Value Z were determined before and after treatment.
4.The aim was to explore the possible lithogenic role of aminopeptidase N (APN) in experimental gallstone formation in rabbits with high cholesterol diet.
5.In aqueous solution and in lithogenic urine, not only the transformation rate of COD into COM was higher, but also was higher the aggregation degree of the transformed product COM crystals.
6.This study suggests that DCA is a lithogenic bile acid and the increased amount of DCA or the ratio of DCA/CDCA in serum may beone of the features of CS patients.
7.(2) We have established a critical table of UCB saturation solubility under pH 7.0, CSI 1.0, in which BSI can be used to discriminate lithogenic and nonlithogenic bile.
8.The expression level of SCP_2 mRNA was respectively related to its own bile lithogenic index(LI) in CON group,HCD group,LVT group,YCH group and FZH group.
9.The integrated opticasl density (IOD) ratio value of mRNA for APN gene was much higher in lithogenic group (1 08±0 35) than that of control and piperine prevention groups (0 65±0 18 and 0 87±0 44 respectively). The enzymatic activity of APN was 6 1±2 53 U/L, 8 31±6 47 U/L and 23 6±10 36 U/L in control, piperine prevention and lithogenic group respectively.
10.Method The experimental cholesterol gallstones(CHS) were conduced in young golden syrian hamsters by a high glucose and fat free lithogenic diet, and the experimental pigment gallstones (PS) were conduced in adult golden syrian hamsters with a low protein diet.
