peripheral nervous system
2.Unlike peripheral nervous system (PNS) axons, severed central nervous system (CNS) axons are unable to regenerate.
5.Adult mammalian neurons in peripheral nervous system (PNS) differ from that in central nervous system (CNS) in their response to injury, the former can successfully regenerate while the latter can not after axotomy.
6.It is suggested that apoptosis is an important clearance mechanism of infiltrated T cells in the peripheral nervous system(PNS) in EAN.
7.Jarman, A. P., et al. "Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system." Cell 73, 7 (1993): 1307-21.
8.One big difference existing between central nervous system (CNS) and peripheral nervous system (PNS) is that injuried axons of CNS could not regenerate any more while nerves in PNS could. The specific and unfriendly surroundings of CNS,especially CNS myelin,which is quite different from that of PNS,contribute a lot to the regeneration failure.
9.EAN can be induced in Lewis rat by immunization with peripheral nervous system myelin or with the P2 protein or P0 protein or synthetic P2 peptides or P2 protein-specific lymphocyte lines. The animal model is very convenient for further scientific research.
10.Both CGT and CalpainⅡare expressed in Schwann cells, the myelin forming cells in peripheral nervous system. However, the expressions of CGT and calpainⅡin sciatic nerves, especially in Schwann cells in experiment DPN and their implication in the pathogenesis of DPN are not reported.
