replication repair
1.Proliferating cell nu clear antigen (PCNA) plays a vital role in regulating cell replication, repair, and death, and is found in an altered form in breast cancer cells.
2.Proliferating cell nuclear antigen (PCNA) is a growth-regulated protein which coordinates events in DNA replication, DNA repair, cell cycle control and epigenetic inheritance. PCNA gene is regulated at both transcriptional and post-transcriptional levels.
3.Proliferating cell nuclear antigen (PCNA) performs essential functions in DNA replication, DNA repair, and cell cycle control. In the present study, we comprehensively examined the putative elements in the promoter region from . 538 to +60 relative to the transcription start site of the human proliferating cell nuclear antigen gene.
4.Results: 341 genes among the total 4096 (8. 33%) showed expression difference in the cDNA chip assessments. The 297 genes (87.1%, ratio <0.5) were down-regulated and 44 gene (12. 9%, ratio>2) were up-regulated, involving multiple scopes as apoptosis, cell cycle, signal transduction, transcription factor, DNA replication, DNA repair, RNA processing and protein synthesis, energy metabolism, immunity-associated, cell receptors as well.
5.There are many processes related to exonuclease activity in mammalian cells; for example, DNA replication, DNA recombination and DNA repair. The exonuclease activity of P53Δ37 protein may be important in these processes.
6.hMLHI gene, one of the six human mis-match repair(MMR)gene, is a tumor-suppressor gene that locates the region 3p21.3-22. MMR could renovate base mismatch during the DNA replication progress, eliminate the unpaired base sequence because of the genetic recombination among the homologies with the simple repeated order and avoid effectively the production of DNA replication errors (RER).
