structural variant
1.Structural studies ofthe variant showed that the alanyl residue in the 26th positon of α-chain is substi-tuted by glutamyl residue and the hemoglobin may be represented as α26(B7)Ala→Glu.
4.All of them showed no clinical symptom or hematological abnormality and structural analysis demonstrated that this variant was Hb New York [β113 (Gl5)Val→Glu].
5.n a survey for abnormal hemoglobins in Wuhai City,a slow moving abnormal hemoglobin was found in an adult male of Mongolia nationality,having electrophoretic mo-bility similar to that of HbG. No ciinical symptom or sign was noticed. Structural analysisdemonstrated that this variant was HbG Taipei[a2β22(B4)Glu→Gly].
6.primary structural analysis of a fast moving variant hemoglobin—Hb Lome(β59(E3)Lys→Asn)found in Henan.
7.No clinical symptom or sign was noticed. Structural analysis demon-strated that the variant is Hb Ottawa(α15(A13)Gly→Arg).
8.ABNORMAL HEMOGLOBINS FOUND NI GUANGDONG PROVINCE: Ⅲ、The Structural Analysis of A New Hemoglobin Variant, Hb—Guangzhou[α~64(E13)Asp→Gly
9.Two kinds of variant of HbJ Tashikuergan [α??19?(AB??1?)Ala→Glu] and HbD Punjab[P??121?(GH4)Glu→Gln] were found in the structural analysis of 8 cases of abnormal hemoglobin.
10.The levels of the hemoglobin variant in the affected individuals were approximately 50%. The affected members of the kindred exhibited erythrocytosis. Structural characterization demonstrated that lysine at the-position of β 144 (HC1) is replaced by asparagine, known as Hb Andrew-Minneapolis (β 144 (HC1) Lys→Asn).
