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1.Methods The following tests were done according to the requirements of developing new drugs. ①The MTD (maximal tolerance dose )test on IRC rats.
方法　按新药的有关要求作如下试验 :①IRC小鼠最大耐受量 (MTD)试验。收藏指正
2.Therefore, according to the requirements of the new drug method of examination and approval, MTD was determined. The maximal tolerance dose of N,O-carboxymethyl chitosan given orally was 10.5g/(kg·bw), which was 3500 times higher than its clinical recommended dose;
鸡灌服给予N,O-羧甲基壳聚糖的最大耐受量为10.5g/(kg·bw),相当于临床拟用量的3500倍;收藏指正
3.RESULTS: The maximal tolerance dose (MTD) im or iv in mice was 4. 4×109 IU m~2, 4400 times the recommended clinical dosage (1×106 IU m~2).
结果:Hu-rIFN-γ对小鼠im或iv的最大耐受剂量为4.4×109 IU m~(-2).收藏指正
4.Methods:1 Test of the maximal tolerance dose:20 Kun Ming mice in health,which weigh 20 + 5 g were administed at doses of 5.94g/20g for two times .
1 最大耐受量实验：选用健康昆明种小鼠20只，雌雄各半，体重为20±5g，分别给予加味甘麦大枣汤煎剂(5.94g／20kg)1ml灌胃，每天2次；收藏指正
5.The results show as follow:1. By gastrogavage , the maximum tolerance dose (MTD) of Eucommia ulmoides extract is over 18.52g/kg weight. The median lethal dose(LD50) of mice intraperitoneally injected Eucommia ulmoides extract solution is 2.57±0.15g/kg,95%of the limit of trust is 2.73 g/kg~2.42g/kgo .
1、灌胃杜仲提取物稀释液，小鼠的最大耐受量(MTD)大于18.52g／kg体重，腹腔注射杜仲提取物稀释液小鼠的半数致死量为2.57±0.15g／kg，95％可信限为2.73g／kg～2.42g／kg。收藏指正
6.There are three parts in the thesis:Part Ⅰ The experiment on acute toxicity of APN soft capsulesWe observed that the maximum tolerance dose(MTD) of APN soft capsules on mice, administered orally, is 110.25(crude drug)/kg, and no acute toxicity reaction has been observed.
预试验未能求得穿心莲软胶囊灌服小鼠半数致死量(LD_(50)),用最大耐受量法求得穿心莲软胶囊灌服小鼠1日最大耐受量为110.25g(生药)/kg。收藏指正
7.Bupivacaine (0.5 -1.5mg/kg iv ) could significantly antagonize arrhythmias. induced by aconitine and BaCI2 in rats(P<0.05 or P< 0. 01 ), prevent ventricular fibrillation induced by chloroform in mice (P<0. 05 or P<0. 01 ), increase tolerance dose of ouabain to produce arrhythmias and cardiac arrest in guinea pigs (P<0. 05 or P<0. 01 ).
布吡卡因0．5、1．0、1．5mg／kg静注能明显对抗乌头碱和氯化钡诱发大鼠的心律失常，预防氯仿诱发小鼠的室颤，增加哇巴因引起豚鼠心律失常及死亡耐受量，与生理盐水对照组比较有显著差异（P<0.05或P<0.01）。收藏指正
8.Results NO-1886 reduced postprandial serum TG and FFA levels of New Zealand rabbits during the fat-tolerance test in dose-dependent manner.
结果NO1886能有效地降低脂负荷后新西兰兔血清甘油三酯和游离脂肪酸水平,呈剂量依赖性,并能使游离脂肪酸恢复到正常。收藏指正
9.AIM:To investigate the feasibility of human cytidine deaminase gene(CD gene) transferred into mouse bone marrow cells and observe the tolerance of bone marrow cells to high dose arabinosylcytosine(Ara C).
目的:探讨人胞苷脱氨基酶基因(CD)导入小鼠骨髓细胞中,观察小鼠骨髓细胞对大剂量阿糖胞苷的耐受性。收藏指正
10.ETX following 28 day resting and, no accumulative tolerance to ETX was developed in the rabbits received six repeated dose of ETX.
重复iv 6 次ETX 对家兔无积蓄耐受作用。收藏指正
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